The systemic lupus activity measurerevised slamr, the mexican version of the systemic lupus erythematosus disease activity index mexsledai and the modified sledai2000 modified sledai2k are reasonable alternatives to the sledai2k instrument for the assessment of disease activity in patients with systemic lupus erythematosus sle. Clinical support delivering highquality clinical care is a central priority for rheumatologists and others who care for patients with rheumatic disease. Find resources to help you deliver the best care possible and measure your actions and decisions for purposes of quality improvement andor reporting. The systemic lupus activity measurerevised, the mexican systemic. Ln is associated with significant morbidity and mortality and is the most common secondary glomerulonephritis leading to endstage renal disease. Pdf measurement of disease activity in systemic lupus. The study was approved by institutional ethic committee. Just to get an idea of what the scores mean, 0 to 5 is mild disease activity, 6 to 12 is moderate disease activity, and over 12 represents severe activity this is just a generalization. A few modifications of sledai index have been made mexsledai. Dalam kegiatan organisasinya, papdi memiliki beberapa kegiatan rutin yang diselenggarakan untuk menjaga kompetensi sejawat internis. The purpose of this study was to evaluate serum leptin levels in systemic lupus erythematosus sle. Sle patients with excess weight bmi 25 kgm2 showed a higher score of clinical activity mexsledai 2.
Paper open access correlation between the percentage of. Sledai is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms. New classification criteria for systemic lupus erythematosus. Jul 20, 2015 measuring lupus disease activity accurately remains a challenging and demanding task given the complex multisystem nature of lupus, an illness known for its variability between patients and within the same patient over time. Systemic lupus erythematosus disease activity index. British isles lupus assessment group bilag index and bilag2004. Sanchezguerrero, instituto nacional ciencias medicas y nutricion, mexico city, august 2002. The sledai and its modifications measure disease activity based on 24 questions assessing the clinical manifestations of sle, including physical findings and laboratory values weighted across organ systems. Apr 28, 2009 in order to test the hypothesis that stratification of mexican modification of the systemic lupus erythematosus disease activity index mex sledai simplifies the genetic study of sle, we evaluated the genetic susceptibility to inflammation and defects in clearance of immune complexes among sle patients in taiwan. The modifications of the sledai2k were built into the mexsledai discussed with dr. Vitamin d insufficiency and deficiency in mexican patients. Apr 26, 2014 median selena sledai score of all patients was 2 iqr 07, while median selena sledai score of patients with active sle was 8 iqr 710. Lupus nephritis ln is one of the most frequent manifestations of sle and can be present in 60% of sle patients. The s2k ri50 comprises the same 24 descriptors, covering 9 organsystems, and reflecting disease activity over the previous 30 days as in sledai2k 30 days.
Mex sledai is a shorter form of mexican systemic lupus erythematosus disease activity. A patients total score is the sum of all marked slerelated descriptors. The sle responder index sri has been successfully used to identify responders in recent trials. Fortyone women with sle were compared with 23 healthy women of similar age and body mass index bmi. The mcid is defined as the smallest difference in a score of a disease measure of. The s2k ri50 comprises the same 24 descriptors, covering 9 organsystems, and reflecting disease activity over the previous 30 days as in. The influence of socioeconomic and race in damage score in. The systemic lupus activity measurerevised, the mexican systemic lupus erythematosus disease activity index sledai, and a. Mexsledai score has a score range of 0 to 32, where the higher the score indicates the more severe the activity of sle disease. Selenasledai is an objective assessment of overall disease activity 1. We studied 92 sle patients from 3 us geographic areas.
Measuring disease activity in adults with systemic lupus. All confounders were evaluated at or before baseline, and disease activity indices were evaluated as a timedependent variable. Socioeconomic status was evaluated by monthly income and years of formal education. The disease remissionactivity presented at enrollment in the study was evaluated by the mexicansystemic lupus erythematosusdisease activity index mexsledai which is a validated activity. In the text below the form there is in depth information on the score and instructions on the items it consists of. The role of neutrophyl lymphocyte count ratio as an. Research open access measuring eosinophiluria, urinary. Assessment measures in systemic lupus erythematosus core. In particular, the excess weight increased the mexsledai score. If descriptor is present at the time of visit or in the proceeding 10 days wt present descriptor definition 8 seizure recent onset.
Pbmc isolation pbmc were isolated using lymphoprep and centrifugation velocity of 1600 rpm, 30 minutes. Measures of disease activity and damage in pediatric systemic. Measures of disease activity and damage in pediatric. One thousand threehundred and twentyone patients were included, median 25 th 75 th age at diagnosis was 27. The systemic lupus activity measurerevised, the mexican.
The original version was published in 1988, and the updated version bilag2004 was published in 2005. The maximum theoretical score for the selena sledai is 105 all 24 descriptors present simultaneously with 0 indicating inactive disease. Score score of 25 indicates the possibility of flare. Severity of disease activity were assessed using mexsledai score, percentage of memory th cells, memory tc cells were examined using flow cytometry and ifn. Disease activity was categorized as mild mex sledai score score 212. It consists of 24 weighted clinical and laboratory variables of nine organ systems. Changes in selena sledai scores over time stratified according to the baseline selena sledai score. Systemic lupus erythematosus disease activity index sledai. The disease remissionactivity presented at enrollment in the study was evaluated by the mexican systemic lupus erythematosusdisease activity index mex sledai which is a validated activity. Assessment measures in systemic lupus erythematosus. The sledai score was calculated from the database according to both the original and. Systemic lupus erythematosus disease activity index 2000. Activity categories have been defined on the basis of the sledai score.
To assess the validity, reliability, and feasibility of the systemic lupus activity measurerevised slamr, the mexican version of the systemic lupus erythematosus disease activity index mexsledai, and a modified sledai2000 sledai2k compared with the sledai2k in a multiethnic population of patients with sle. Ethical clearance for this study has been approved by dr saiful anwar hospital ethics committee. Indices to assess patients with systemic lupus erythematosus. The sledai2k descriptors, definitions, and weighted scores are presented in table 3. Of this cohort, 22 patients had inactive disease, while 36 had probably active disease and 15 patients had clearly active disease. Beberapa kegiatan tersebut antara lain pertemuan ilmiah nasional pin, roadshow di cabang papdi, round table discussion rtd dan masih banyak kegiatan lainnya. Pdf the systemic lupus activity measurerevised, the.
All acronyms has a list of 1 mex sledai definition. Assesses disease activity by scoring 24 weighted disease activity descriptors of sle as present or absent in preceding 10 days. Serum leptin levels in women with systemic lupus erythematosus. The disease remissionactivity presented at enrollment in the study was evaluated by the mexicansystemic lupus erythematosusdisease activity index mex sledai which is a validated activity. The bilag index, an organbased transitional activity instrument, provides disease activity scorings across eight organ systems on an ordinal scale a to e based on the physicians intentiontotreat premise. Nafld fibrosis score reduce the need for liver biopsy by identifying patients with nonalcoholic fatty liver disease likely or unlikely to have advanced fibrosis meld score age above 12 years scoring system used to rank prioritize candidates for liver transplantation, including meldna used in the optn match system alcohol relapse risk after. Selena sledai score of patients with active sle was 8 iqr. The systemic lupus activity measurerevised slamr, the mexican version of the systemic lupus erythematosus disease activity index mex sledai and the modified sledai 2000 modified sledai 2k are reasonable alternatives to the sledai 2k instrument for the assessment of disease activity in patients with systemic lupus erythematosus sle. The disease remissionactivity presented at enrollment in the study was evaluated by the mexicansystemic lupus erythematosusdisease activity index mexsledai 27 and the chronicity was. Systemic lupus erythematosus disease activity index 2000 mdcalc. In most sle patients, the intensity of disease activity evaluated with mexsledai was mild to moderate, with a median interquartile range score of 2 08. The exclusion criteria were subjects with infection, severe disease activity, treatment with cyclophosphamide in the last 28 days, azathioprine or methotrexate. This sle disease activity index sledai calculator determines changes in the disease activity of patients diagnosed with lupus erythematosus.
The sledai is a global index that was developed and introduced in 1985 as a clinical index for the assessment of lupus disease activity in the preceding 10 days. Sledai has the advantage of avoiding the cost of immunologic laboratory tests because it does not include antidouble. Selenasledai systemic lupus erythematosus disease activity. In agreement with the presence and absence of activity, 31 patients 22. S2k ri50 is a reliable and valid index able to demonstrate incomplete but clinically significant. Clinical characteristics and mexican systemic lupus erythematosus disease activity index mexsledai score were assessed. Bencivelli w, vitali c, isenberg da, smolen js, snaith ml, sciuto m, bombardieri s. September 1996 to may 1997 mexico city 180 pa7ents visited er 164 females mean age. A sledai score 5 is associated with a probability of initiating therapy in 50% of cases. Mexican systemic lupus erythematosus disease activity. Disease activity was calculated using sledai score.
If descriptor is present at the time of visit or in the proceeding 10 days. Its correlation with the experts visual analogue scale vas was similar to sledai r s 0. Lupus flare or active lupus is defined as the mexsledai score 5. Experimental study consisted of 29 samples of sle patients, divided into 2 groups, namely sle patients who received moringa oleifera leaf extract as much as. For comparison we examined the hematology parameter of. Median selena sledai score of all patients was 2 iqr 07, while median selena sledai score of patients with active sle was 8 iqr 710. Similar models were applied for the sledai and the mex sledai.
The median sledai score of these sle patients was 9 6, 12, and the actual median dose of corticosteroids was 15 10, 45 mgd. A score reduction, ie, the disappearance of a scored parameter, requires either the complete resolution of a disease manifestation or laboratory test value. To assess the validity, reliability, and feasibility of the systemic lupus activity measurerevised slamr, the mexican version of the systemic lupus erythematosus disease activity index mex sledai, and a modified sledai 2000 sledai 2k compared with the sledai 2k in a multiethnic population of patients with sle. Mexsledai mexican systemic lupus erythematosus disease. Sle phenotypes were stratified according to the mex sledai scores into two. The sledai 2000 sledai2k responder index 50 sri50 is a novel index that measures. The sle activity index was applied using the mexsle dai, an instrument validated for the mexican population, which considers a mexsledai score 9 to be active lupus and mexsledai score is a simple method that is quite valid for finding the degree of sle activity, and mex sledai has the ability to evaluate clinical changes in sle patients. This is a weighted index in which signs and symptoms, laboratory tests, and physicians assessment pga for each of nine organ systems are given a weighted score and summed up if present at the time of the visit or in the preceding 10 days. Pdf the systemic lupus activity measurerevised, the mexican. The sledai does not record improving or worsening, and does not include severity within an organ system. This type of index is the most commonly used and one of the two major scoring systems along bilag that evaluate the activity of lupus erythematosus. The eclam includes 10 organ systems and two laboratory measures, esr and serum complement, for a total of 33 items that are scored from 0. Nutrients free fulltext relationship of excess weight. Indices to assess patients with systemic lupus erythematosus in clinical trials, longterm observational studies, and clinical care.
Systemic lupus erythematosus sle is a prototypic autoimmune disease with the potential to affect a variety of end organs. The disease remissionactivity presented at enrollment in the study was evaluated by the mexicansystemic lupus erythematosusdisease activity index mex sledai 27 and the chronicity was. This modified score includes 24 specifically defined main variables grouped by target organ, with a maximum score of 32 points. The systemic lupus activity measurerevised, the mexican systemic lupus. It is based on the sledai 2000 or sledai 2k score, a modification of the original sledai score. The clinical characteristics of the patients are shown in table 1.